Synergistic impact of polyherbal formulations on metabolic syndrome: a comprehensive review of mechanisms and therapeutic potential

Peter M. Besada, Ahmed M. Abdelaziz, Ahmed R. Rabie, Dina M. Mahdy

Abstract


Obesity, dyslipidemia, hypertension, and insulin resistance are all components of metabolic syndrome, which significantly increases the risk of cardiovascular diseases and type 2 diabetes. Current conventional pharmacological therapies typically have limited efficacy and might induce side effects, highlighting the need for innovative therapeutic strategies. This mini-review looks at polyherbal formulations' potential as an effective multi-target therapy for metabolic syndrome, which may offer a more suitable alternative for the current monotherapy agents. Drawing from current research, our team investigates how these formulations provide anti-obesity, antihyperglycemic, and hypolipidemic effects. Bioactive compounds in herbs such as Citrus reticulata, Momordica Charania, and Glycine max collaborate to enhance lipid metabolism, reduce adipogenesis, and strengthen antioxidant defense. This Research also checks the safety profiles and therapeutic potential of these formulations to relieve the complicated symptoms resulting from metabolic syndrome. This study reinforces the opportunity of using herbal medications as a comprehensive approach to manage metabolic syndrome, paving the way for further clinical studies creating standardized herbal medications.

 

Received on, 03 May 2025

Accepted on, 04 October 2025

Published on, 11 November 2025


Keywords


“Polyherbal Formulation”; “Metabolic Syndrome”; “Anti-Hyperglycemia”; “Anti-Obesity”; “Herbal Medicine” ; “Hypolipidemic” ; “Antihypertensive”

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References


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DOI: https://dx.doi.org/10.21622/AMPDR.2025.05.2.1325

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Copyright (c) 2025 Peter M. Besada, Ahmed M. Abdelaziz, Ahmed R. Rabie, Dina M. Mahdy

Advances in Medical, Pharmaceutical and Dental Research

E-ISSN: 2812-4898

P-ISSN: 2812-488X

 

Published by:

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Arab Academy for Science, Technology and Maritime Transport (AASTMT)

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ampdr@aast.edu