Effect of platelet rich fibrin on post-operative sequelae following mandibular third molar surgery a prospective comparative study

Chayan Kumar Kundu, Pratyaee Mallick, Sudip Chakraborty

Abstract


Objectives: The purpose of this study is to estimate the effect of Platelet Rich Fibrin (PRF) on the control of post-operative sequalae i.e. Pain, Trismus, Swelling and Incidence of Alveolar Osteitis (AO) following mandibular third molar surgery

Material and Methods: 26 patients divided into two groups. Group I getting PRF after extraction of third molar while Group II did not get any PRF. Post-surgical Pain, Swelling, Trismus, Incidence of AO was evaluated.

Results: It was found that Group II had greater pain scores than Group I assessed by VAS, with statistically significant greater score after 2 hours (P=0.0014) and 12 hours (P=0.0063). In case of swelling, Site II shown statistically significant difference in 7th day (P=0.007), and 14th day (P=0.04), Site III shown statistically significant difference in 3rd day (P=0.005), 7th day (P=0.03), and Site IV shown statistically significant difference in only in 3rd day (P=0.004). Inter-incisal distance was higher for Group I than Group II, statistically significant on 7th day (P=0.0069) and 14th day (P=0.0008). This study did not find any incidence of AO in both groups

Conclusions: PRF appears to be beneficial and effective in lowering postoperative sequalae in mandibular third molar surgery. PRF effectively decreases Pain, Swelling and Trismus when compared with case and control group. However, this study cannot comment on effectiveness of PRF on incidence of alveolar osteitis

 

Received: 26 September 2024

Accepted: 31 October 2024

Published: 20 November 2024


Keywords


Dry Socket; Pain; Platelet-Rich Fibrin; PRF; Swelling; Third Molar; Trismus;

Full Text:

PDF

References


Suarez-Cunqueiro MM, Gutwald R, Reichman J, Otero-Cepeda XL, Schmelzeisen R. Marginal flap versus paramarginal flap in impacted third molar surgery: A prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(4).

Steed MB. The indications for third-molar extractions. Journal of the American Dental Association. 2014;145(6).

Dodson T, Susarla S. Impacted wisdom teeth. BMJ Clin Evid. 2014;

Candotto V, Oberti L, Gabrione F, Scarano A, Rossi D, Romano M. Complication in third molar extractions. J Biol Regul Homeost Agents. 2019;33(3).

Cho H, Lynham AJ, Hsu E. Postoperative interventions to reduce inflammatory complications after third molar surgery: review of the current evidence. Vol. 62, Australian Dental Journal. 2017.

Bone growth after tooth extractions examined. Vol. 208, British dental journal. 2010.

Ghanaati S, Herrera-Vizcaino C, Al-Maawi S, Lorenz J, Miron RJ, Nelson K, et al. Fifteen years of platelet rich fibrin in dentistry and oromaxillofacial surgery: How high is the level of scientific evidence? Vol. 44, Journal of Oral Implantology. 2018.

Choukroun J, Adda F, Schoeffer C. The opportunity in perio-implantology: The PRF. Implantodontie. 2001;(42):55–62.

Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Vol. 27, Trends in Biotechnology. 2009.

Kumar N, Prasad K, Ramanujam L, Ranganath R, Dexith J, Chauhan A. Evaluation of treatment outcome after impacted mandibular third molar surgery with the use of autologous platelet-rich fibrin: A randomized controlled clinical study. Journal of Oral and Maxillofacial Surgery. 2015;73(6).

Del Fabbro M, Corbella S, Taschieri S, Francetti L, Weinstein R. Autologous platelet concentrate for post-extraction socket healing: a systematic review. Eur J Oral Implantol. 2014;7(4).

Al-Hamed FS, Tawfik MAM, Abdelfadil E, Al-Saleh MAQ. Efficacy of Platelet-Rich Fibrin After Mandibular Third Molar Extraction: A Systematic Review and Meta-Analysis. Vol. 75, Journal of Oral and Maxillofacial Surgery. 2017.

Canellas JVDS, Medeiros PJD, Figueredo CMDS, Fischer RG, Ritto FG. Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis. Vol. 48, International Journal of Oral and Maxillofacial Surgery. 2019.

De Menezes SAF, Cury PR. Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar. Int J Oral Maxillofac Surg. 2010;39(6).

Al-Hamed FS, Tawfik MAM, Abdelfadil E. Clinical effects of platelet-rich fibrin (PRF) following surgical extraction of lower third molar. Saudi Journal for Dental Research. 2017;8(1–2).

Da Silva T, De Almeida Barros Mourão CF, Mello-Machado RC, Montemezzi P, De Lima Barbosa R, Sartoretto SC, et al. Effects of leukocyte-platelet-rich fibrin (L–prf) on pain, soft tissue healing, growth factors, and cytokines after third molar extraction: A randomized, split-mouth, double-blinded clinical trial madelaine. Applied Sciences (Switzerland). 2021;11(4).

Miyamoto H, Nakamura T, Takashima H, Mizutani T, Morita M, Hirose M, et al. Investigation of the analgesic effect of platelet-rich fibrin on postoperative pain after mandibular impacted wisdom tooth extraction. J Oral Maxillofac Surg Med Pathol. 2020;32(4).

Kim JH, Lee DW, Ryu DM. Effect of platelet-rich fibrin on pain and swelling after surgical extraction of third molars. Tissue Eng Regen Med. 2011;8(SUPPL.2).

Ozgul O, Senses F, Er N, Tekin U, Tuz HH, Alkan A, et al. Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: Randomized multicenter split-mouth clinical trial. Head Face Med. 2015;11(1).

Nasirzade J, Kargarpour Z, Hasannia S, Strauss FJ, Gruber R. Platelet-rich fibrin elicits an anti-inflammatory response in macrophages in vitro. J Periodontol. 2020;91(2).

Zhang J, Yin C, Zhao Q, Zhao Z, Wang J, Miron RJ, et al. Anti-inflammation effects of injectable platelet-rich fibrin via macrophages and dendritic cells. J Biomed Mater Res A. 2020;108(1).

Kargarpour Z, Panahipour L, Mildner M, Miron RJ, Gruber R. Lipids of Platelet-Rich Fibrin Reduce the Inflammatory Response in Mesenchymal Cells and Macrophages. Cells. 2023;12(4).

Harsh DA. Evaluation of Role of Autologous Platelet Rich Fibrin in Wound Healing and Bone Regeneration after Mandibular Third Molar Surgery: A Prospective Study. Journal of Medical Science And clinical Research. 2018 May 9;6(5).

Zahid TM, Nadershah M. Effect of advanced platelet-rich fibrin on wound healing after third molar extraction: A split-mouth randomized double-blind study. Journal of Contemporary Dental Practice. 2019;20(10).

Bilginaylar K, Uyanik LO. Evaluation of the effects of platelet-rich fibrin and piezosurgery on outcomes after removal of ımpacted mandibular third molars. British Journal of Oral and Maxillofacial Surgery. 2016;54(6).

Asutay F, Yolcu U, Geçör O, Acar A, Öztürk S, Malkoç S. An evaluation of effects of platelet-rich-fibrin on postoperative morbidities after lower third molar surgery. Niger J Clin Pract. 2017;20(12).

Nourwali I. The effects of platelet-rich fibrin on post-surgical complications following removal of impacted wisdom teeth: A pilot study. J Taibah Univ Med Sci. 2021;16(4).

Borsani E, Bonazza V, Buffoli B, Cocchi MA, Castrezzati S, Scarì G, et al. Biological characterization and in vitro effects of human concentrated growth factor preparation: An innovative approach to tissue regeneration. Biology and Medicine. 2015;7(5).

Jeyaraj PE, Chakranarayan A. Soft tissue healing and bony regeneration of impacted mandibular third molar extraction sockets, following postoperative incorporation of platelet-rich fibrin. Ann Maxillofac Surg. 2018;8(1).

Shruthi TM, Shetty AD, Akash KS, Ahmed F, Shetty N, Singarapu R. Evaluation of effects of platelet-rich fibrin on treatment outcomes after impacted mandibular third molar surgery: A randomized controlled clinical study. Natl J Maxillofac Surg. 2022;13(4).

GÜRLER H, DEMİR P. NASAL OBSTRUCTION, QUALITY OF LIFE AND COMFORT LEVEL IN SEPTORINOPLASTY PATIENTS: SIX-MONTHLY MONITORING STUDY. Turkish Journal of Science and Health. 2023;

Asutay F, Ozcan-Kucuk A, Alan H, Koparal M. Three-dimensional evaluation of the effect of low-level laser therapy on facial swelling after lower third molar surgery: A randomized, placebo-controlled study. Niger J Clin Pract. 2018;21(9).

Abdul-Kareem AS, Al-Hussaini AH. Effect of platelet rich-fibrin on alveolar osteitis incidence following surgical removal of impacted mandibular third molars: A comparative study. Journal of Baghdad College of Dentistry. 2019;31(4).

Eshghpour M, Dastmalchi P, Nekooei AH, Nejat A. Effect of platelet-rich fibrin on frequency of alveolar osteitis following mandibular third molar surgery: A double-blinded randomized clinical trial. Journal of Oral and Maxillofacial Surgery. 2014;72(8).




DOI: http://dx.doi.org/10.21622/AMPDR.2024.04.2.1031

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Chayan Kumar Kundu, Pratyaee Mallick, Sudip Chakraborty

Advances in Medical, Pharmaceutical and Dental Research
E-ISSN: 2812-4898
P-ISSN: 2812-488X 

Published by:

Academy Publishing Center (APC)
Arab Academy for Science, Technology and Maritime Transport (AASTMT)
Alexandria, Egypt
ampdr@aast.edu