Myxoid angiomatoid fibrous histiocytoma. report of an uncommon neoplasm with a literature review

Marwa Mohamed Abd El Aziz, Rania Gaber Aly, Samir S Amr

Abstract


Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor usually seen in the extremities of children and adolescents. Classically AFH presents as a painless cystic mass that shows blood filled spaces on cut section and bland histiocyte-like cells on microscopic examination. Predominance of myxoid stroma is a rare finding in AFH, usually seen with other classical features. We herein report a case of myxoid AFH with both unusual clinical presentation and uncommon histopathological features with a review of literature.


Keywords


Myxoid, Angiomatoid fibrous histiocytoma.

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References


WHO Classification Of Tumours Editorial Board. Soft tissue and bone tumours, 5th ed. Lyon: IARC, 2020. P. 283-284.

Enzinger FM. Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer. 1979; 44 (6):2147–2157. https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/1097-0142(197912)44:6%3C2147::AID-CNCR2820440627%3E3.0.CO;2-8

Chen G, Folpe AL, Colby TV, et al. Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology. Mod Pathol. 2011; 24 (12):1560–1570. https://www.nature.com/articles/modpathol2011126

Akiyama M, Yamaoka M, Mikami-Terao Y, et al. Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion–induced excessive interleukin-6 production. J Pediatr Hematol Oncol. 2015; 37 (7): 554–559. https://www.ingentaconnect.com/content/wk/jpho/2015/00000037/00000007/art00024

Soft tissue tumors of intermediate malignancy of uncertain type. In Enzinger and Weiss’s soft tissue tumors, Goldblum JR, Folpe AL, Weiss S. 7th ed. Philadelphia: Elsevier. 2020. Pp.1107-68.

Costa MJ, Weiss SW. Angiomatoid malignant fibrous histiocytoma: a follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. Am J Surg Pathol. 1990; 14 (12):1126–1132. https://europepmc.org/article/med/2174650

Bohman SL, Goldblum JR, Rubin BP, et al. Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum. Pathology. 2014; 46 (3):199–204. https://www.sciencedirect.com/science/article/pii/S0031302516306043

Yu-Chien Kao, Jui Lan, Hui-Chun Tai et al: Angiomatoid fibrous histiocytoma: clinicopathological and molecular characterisation with emphasis on variant histomorphology. J Clin Pathol. 2014; 67:210–215. https://jcp.bmj.com/content/67/3/210.short

Schaefer IM, Fletcher CD. Myxoid variant of so-called angiomatoid “malignant fibrous histiocytoma”: clinicopathologic characterization in a series of 21 cases. Am J Surg Pathol. 2014; 38 (6):816–823 https://journals.lww.com/ajsp/Fulltext/2014/06000/Myxoid_Variant_of_So_called_Angiomatoid__Malignant.10.aspx

Thway K, Strauss DC, Wren D, Fisher C. ‘Pure’ spindle cell variant of angiomatoid fibrous histiocytoma, lacking classic histologic features. Pathol Res Pract. 2016; 212 (11):1081–1084. https://www.sciencedirect.com/science/article/pii/S0344033816304058

Pettinato G, Manivel JC, De Rosa G, et al. Angiomatoid malignant fibrous histiocytoma: cytologic, immunohistochemical, ultrastructural, and flow cytometric study of 20 cases. Mod Pathol. 1990; 3 (4):479–487. https://europepmc.org/article/med/2170972

Fanburg-Smith JC, Miettinen M. Angiomatoid “malignant” fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Hum Pathol. 1999; 30 (11):1336–1343. https://www.sciencedirect.com/science/article/pii/S0046817799900655

Cheah AL, Zou Y, Lanigan C, et al. ALK expression in angiomatoid fibrous histiocytoma: a potential diagnostic pitfall. Am J Surg Pathol. 2019; 43 (1):93–101. https://www.ingentaconnect.com/content/wk/ajsp/2019/00000043/00000001/art00010

Antonescu CR, Dal Cin P, Nafa K, et al. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2007; 46 (12):1051–1060. https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.20491

Waters BL, Panagopoulos I, Allen EF. Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11. Cancer Genet Cytogenet. 2000; 121 (2):109–116. https://www.sciencedirect.com/science/article/pii/S0165460800002375

Hallor KH, Mertens F, Jin Y, et al. Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer 2005; 44 (1):97–102. https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.20201

Thway K, Fisher C. Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status. Am J Surg Pathol. 2012; 36 (7):e1–e11. https://journals.lww.com/ajsp/fulltext/2012/07000/tumors_with_ewsr1_creb1_and_ewsr1_atf1_fusions_.1.aspx

Wong SJ, Wee A, Puhaindran ME, Pang B, Lee VK. Angiomatoid fibrous histiocytoma with prominent myxoid stroma: a case report and review of the literature. The American Journal of Dermatopathology. 2015; 37 (8):623-31. https://journals.lww.com/amjdermatopathology/fulltext/2015/08000/Angiomatoid_Fibrous_Histiocytoma_With_Prominent.6.aspx

Ying LX, Teng XD. Myxoid and reticular angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement. International journal of clinical and experimental pathology. 2018; 11 (6):3186. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958084/

Tan NJ, Pratiseyo PD, Wahjoepramono EJ, Kuick CH, Goh JY, Chang KT, Tan CL. Intracranial myxoid angiomatoid fibrous histiocytoma with “classic” histology and EWSR1: CREM fusion providing insight for reconciliation with intracranial myxoid mesenchymal tumors. Neuropathology. 2021; 41 (4):306-14. https://onlinelibrary.wiley.com/doi/abs/10.1111/neup.12737




DOI: http://dx.doi.org/10.21622/ampdr.2022.02.02.022

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Advances in Medical, Pharmaceutical and Dental Research
E-ISSN: 2812-4898
P-ISSN: 2812-488X 

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